Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers
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چکیده
منابع مشابه
Emerging EPO and EPO receptor regulators and signal transducers.
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...
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15 صفحه اولThe Succinate - Glycine Cycle
This aminoketonic acid is the source of all the carbon atoms of protoporphyrin (2-4). In this series of reactions, t.he a-carbon atom of glycine becomes the b-carbon atom of S-aminolevulinic acid. Since the a-carbon atom of glycine, detached from its carboxyl group, is not only utilized for porphyrin synthesis but also conforms to the metabolic pattern of the “Cl” compounds (3), this carbon acy...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.07.030